>Breast Milk: a source of stem cells

>Here’s a link to a (free) commentary (in pdf) on stem cells that are passed back and forth between mothers and their children.

From the Journal of Human Lactation, by James A McGregor, MD, CM and Lisa J. Rogo,

Research shows that breastfeeding provides multiple lifelong biologic advantages to children, including increased survival and improved neurocognitive and immune functioning. These and other advantages have been linked to breast milk components, including longchain fatty acids, epithelial growth factor, immunestimulating cells, and live maternal immune cells (lymphocytes and plasma cells), which survive gastrointestinal
transport and implant in neonatal tissues. Previous research related to stem cells and breastfeeding has focused on the identification of mammary gland stem cells rather than their biologic functions. Gudjonnson and colleagues demonstrated that stemlike cells exist in mammary epithelial cells in humans,
mice, and rats.1 However, these investigators did not evaluate inclusion of stem cells in the cellular components of breast milk, passage to the newborn, or establishment of lactation-derived stem cells in infant tissues. Newer research attempts to characterize the biological activity of mammary stem cells. Boulanger
and colleagues suggested mammary stem cells play roles in mammary epithelial regeneration and hormone responsiveness.2 We propose that maternal stem cells secreted in milk and suckled by the infant may be an important but so far unappreciated live, functional component of breast milk.

Perinatal stem cell research suggests that humans
potentially contain persisting stem cell–like cells derived from perinatal placental cell transfer. Recent research establishes the extent and potential significance of physiologic bi-directional cell transport across the placenta. Differentiated XY chromosomal
cells (presumably fetal) have been found in maternalblood and organs up to 30 years after birth.3,4 Such cells are hypothesized both to provide comparative survival advantages for mothers and to be involved in the pathogenesis of immune-mediated disease such as
scleroderma and thyroiditis. Less well-studied is the reverse, whereby maternal cells cross the placenta and implant in perinatal tissues. Support for this hypothesis is provided by the findings that undifferentiated or pluripotent maternal stem cells have been found in human fetal cord blood,5 and differentiated maternal
cells have been found in human newborn tissues and organs including the liver.6 The physiologic roles and responses to such nonself (maternal) engrafted stem cells remain uncharacterized. We suggest that the mother-to-perinatal engraftment continues postnatally
by way of lactation. We suggest that future research should examine breastfeeding as a physiologic pathway by which the suckling infant receives maternal stem cells. Transportation of maternal stem cells to the breastfeeding infant may be associated with possible benefits (increased populations of progenitor cells that assist with repair of damaged tissues) or cause disease (graft versus host reactions, autoimmune processes, or stem cell–derived neoplasia).

Given that breast milk contains multiple cellular and nonnutritive components and that breast epithelium contains stem cells, we suggest that breast milk may contain stem or pluripotent cells and that these cells may implant and serve various functions in the breastfed individual, and that these cells may be identified
and characterized using newly available stem cell biomarkers. Investigation of proposed vertical stem cell transport through milk may elucidate other potentially powerful biologic benefits of human lactation.

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Conservative Christian Family Doctor, promoting conservative news and views. (Hot Air under the right wing!)


4 thoughts on “>Breast Milk: a source of stem cells

  1. >Stem cell like cells are not stem cells. Therefore these cells need to be characterized and verified to be stem cells using embryonic stem cells! Please be more open to embryonic stem cell research so people do not get the wrongly impression that adult stem cells are readily available as an alternative to ES. In fact, the only therapies available which uses adult stem cells are against lymphoma and leukemia. It took about fory years to develop these.

    Posted by Anonymous | February 15, 2008, 3:50 pm
  2. >There's no reason to verify any of them "using embryonic stem cells." They are verified by growing cultures of the cells themselves in different conditions and testing the resulting cell lines.Although most of the "stem cells" and "stem cell-like cells" that are written about would be better defined as partially differentiated stem cells or progenitor cells, they are found in virtually every organ and tissue of the body. We've been using the bone marrow stem cells for over 40 years, and umbilical cord blood cells for about 10. It is true that the most common real-life use is in treatment of diseases of the blood system. However, they are also used experimentally to treat heart disease, fractures, damaged cartilage, autoimmune disease like lupus and Rheumatoid arthritis, and genetic problems like Hurler's, and the "bubble boy" syndrome. We're learning to treat blood vessel disease caused by diabetes, and it looks like a patient's own cells can be used to treat the diabetic kidney disease. This blog has tons of references and citations.

    Posted by LifeEthics.org | February 19, 2008, 10:30 am
  3. >By the way, Anon, read the February 19th post here, or the news article on adult stem cells, here.

    Posted by LifeEthics.org | February 19, 2008, 4:41 pm
  4. >Another reason to enjoy nursing my son! 🙂

    Posted by Anonymous | February 29, 2008, 10:05 pm

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